May 19, 2024

US scientists realize new breakthrough in nano-diamond dental transplantation

Abstract Researchers at the University of California, Los Angeles (UCLA) have recently made breakthroughs in bone growth and dental implant technology using nano-synthetic diamonds, which has brought good news to patients with dental diseases. Nanodiamonds are only 4 to 5 nm in diameter and are shaped like pocket-sized feet.
Researchers at the University of California, Los Angeles (UCLA) have recently used nano-synthetic diamonds to achieve breakthroughs in bone growth and dental implant technology, bringing good news to patients with dental problems.


The nanodiamond is only 4 to 5 nm in diameter and is shaped like a pocket-shaped football. It is such an industrial grade nanodiamond that is favored by scientists at the University of California, Los Angeles, Department of Dentistry, Department of Bioengineering, and Northwestern University for the treatment of bone growth and osteonecrosis. Osteonecrosis is defined in the medical community as bone ischemia, degeneration, and necrosis, which are further caused by bone nourishment of blood vessels, thereby causing attenuation of other functional bodies of the human body.

Once the osteonecrosis affects the jaw, the normal eating and talking function is immediately affected; once the bone joint is affected, the human body movement is severely hindered and even unable to move normally. In addition, osteoporosis due to joint repair and tooth transplantation also occurs from time to time, and osteoporosis, in turn, adversely affects the affected area and causes pain to the patient.

Repetitive transplant treatment not only brings unnecessary pain to the patient, but also is very expensive. In the mouth, especially in the teeth, if these diseases occur, the consequences are even more unimaginable: due to the special nature of the oral soft tissue, lack of strong bone traction and bone support, the repaired teeth are more prone to necrosis.

The research led by Professor Dr. Dean Ho solved this problem using nano-diamond technology, and the research results were published in the journal Dental Research.

Traditional bone repair requires an invasive surgical procedure in which a cavernous body is implanted in the affected area to locally assist and “manage” proteins that promote bone growth, such as bone morphogenetic proteins.

Professor Dr. Dean Ho's research found that nanodiamonds can effectively carry these proteins directly into the affected parts of the repair, which is more efficient than traditional bone repair techniques. These invisible nanodiamonds are rapidly combined with bone morphogenetic proteins and fibroblast growth factors. This proves that nanodiamond can carry protein treatment in a non-invasive way; the so-called non-invasive, on the one hand, the special physical and biochemical properties of nano-diamonds will not affect the human body, and on the other hand, due to its nano-size, The immune body is almost unaware of these diamond "guards" that are free from the diseased part, so that no drug resistance occurs. Compared with external force invasive treatment, doctors only need to do an intramuscular injection or oral irrigation, no need to open too many incisions, and the patient also relieved a lot of pain.

At the same time, the special physical appearance of nanodiamonds enables slow and orderly protein delivery, thereby extending the effective time of bone repair.

“We have conducted a number of comprehensive cell and animal simulation experiments to verify the safety and reliability of this nanodiamond therapy,” Professor Laura Moore said. “Preliminary studies have shown that nanodiamonds are well tolerated in experiments. Well, this lays a good foundation for future dental implant and bone repair technology applications."

Dr. No-Hee Park, director of the Department of Dentists at the University of California, Los Angeles, commented on the study: Professor Dean Ho's new study opens a new door to the application of nanodiamonds in dentistry, plastic surgery and other medical fields. The advancement and breakthrough of nano-diamond medical technology has brought the gospel to the majority of patients. This is not only the academic honor of Professor Dean Ho, but also the welfare of the society. ”

The study was sponsored by the National Cancer Research Center, the National Science Foundation, the Wallace Corte Foundation, and the European Commission. (Compiled from "Are nanodiamond-encrusted teeth the future of dental implants?")

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